Fix Your Gut

Master Your Microbiome in 3 Simple Steps

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New Zapiens
September 04, 2025

Happy Thursday, Zapien — Here’s what we’re diving into this week:

Forever,
Karol, Martin, Simon & Andy

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The Microbiome Cosmos: How the gut’s invisible residents shape health and longevity

“All disease begins in the gut.” – Hippocrates (ca. 460–370 BC)

Centuries before microscopes existed, Hippocrates and later Paracelsus intuited that our digestive tract is inseparable from health. Today these ancient observations resonate with modern data. Books such as “Darm mit Charme” (in English Gut: The Inside Story of Our Body's Most Underrated Organ from Guilia Enders) popularized the idea of gut health in mainstream culture, and scientific interest exploded into what some now call the microbiome cosmos - the trillions of microbes that coexist within us.
In this article we explore what the human gut microbiome is, why it matters, what a microbiome analysis can and cannot tell you, and how emerging tools like artificial intelligence (AI) and community‑based reference ranges are changing the landscape of personalized health.

Meet your gut microbiome

The human body contains far more microbial passengers than most people realize. Estimates suggest that the gut harbors more than a thousand microbial species and approximately one hundred trillion microbes. These microorganisms - bacteria, archaea, viruses, fungi, phages and more - carry about 150 times more genes than the entire human genome. Collectively, they weigh roughly 1 up to 2.5 kilograms and are sometimes described as a “vital organ” because they communicate with our nervous, endocrine and immune systems through neural, hormonal and metabolic pathways.

Short Hack Long Life

Sauna for cardiovascular health and longevity

Regular sauna bathing is more than just relaxation. Research links it to improved vascular function, reduced cardiovascular risk, and possibly longer lifespan.

A long-term Finnish study showed that using the sauna 4–7 times per week was linked to about a 40% lower risk of dying from any cause compared to once-a-week use. The same study also found lower risks of heart attacks and strokes.

Another study found that even a single 30-minute sauna session can lower blood pressure and improve arterial flexibility. With repeated use, sauna bathing also activates heat-shock proteins that protect cells and support recovery. The benefits appear strongest when frequent sauna use is combined with high cardiorespiratory fitness.

In other words, the science lines up with what people already feel after a good session.

How to sauna for longevity:

🔥 Heat up 80–100 °C
⏱️ Stay 15–20 minutes per session
♻️ Repeat 4-7 sessions per week
💧 Always hydrate well before and after

→ Consistency over years is what brings the biggest benefits.

Backed by decades of research, sauna bathing combines relaxation with measurable benefits for cardiovascular health and, potentially, longevity.

Disclaimer: Sauna use is generally safe for healthy adults, but people with cardiovascular disease, low blood pressure, or other health conditions should consult a doctor before starting frequent sauna sessions.

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WhatsApp Group Summary

Adaptogens & Mushroom Coffee

Discussion: 
Members compared mushroom blends and “coffee” alternatives; experiences varied from feeling calmer to better focus. Brands and taste/preferences differed widely.

Consider this:
• Start simple: try a single-mushroom or clear blend from a reputable brand; note how you feel for 1–2 weeks.
• If you have a condition or take meds, check with a professional before using adaptogens.

Prevention on a Budget

Discussion: 
Members asked what to do if you can’t afford full body scans. Most agreed: get the basics right first (sleep, diet, movement, stress), then use targeted, low-cost tests.

Consider this:
• Prioritize routine blood work (cholesterol profile, blood sugar, inflammation, kidney/liver) 1–2×/year with your doctor.
• Use your insurance’s preventive checkups first; add extras only if they change what you’ll do next.

Plasma Donation vs. TPE

Discussion: 
Members debated claims around plasma donation versus therapeutic plasma exchange (TPE). Some personal positives were shared, but evidence for similar benefits to TPE is unclear.

Consider this:
• Treat plasma donation as a personal choice, not a longevity shortcut; discuss risks (e.g., iron, protein, immune markers) with a professional.
• If you experiment, track how you feel and review labs with your doctor before making it routine.

Community Health Stack

Dave Asprey

Serial entrepreneur and founder of Bulletproof. Biohacking advocate focused on low-carb, high-fat nutrition, performance optimization, and longevity strategies.

Dave's Trusted Brands

Dave's Health Routine

Routine
• Wake-Up: Natural rise after ~6.5 h sleep
• Hydration: Water with sea salt + lemon
• Morning Light: Sun exposure or light therapy
• Coffee Ritual: Bulletproof Coffee (butter + MCT oil)
• Work Start: Phone on airplane mode, deep work focus
• Movement Breaks: Walking or light activity during day
• Air Quality: Filters and oxygen optimization at home
• Evening Light: Red light and blue-blocking glasses
• Bedtime: Consistent schedule, smart mattress cooling

Workout
• Strength: Weekly focus cycles
• HIIT: Alternating with strength weeks

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Health Disclaimer

New Zapiens’ products and services are not intended to substitute for professional medical guidance. Our content and media offerings do not aim to diagnose, cure, or address any medical issues.

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